Mechanism of Action

Albendazole exhibits a broad-spectrum anthelmintic activity showing vermicidal, ovicidal and larvicidal actions. It inhibits tubulin polymerization in the parasite and blocks glucose uptake; energy levels are reduced resulting to death of the parasite. Susceptible parasites include hookworm, roundworm, threadworm, whipworm, tapeworm, strongyloides, opisthorchis and hydatid disease (Echinococcus).

Poorly absorbed from the GI tract (oral).

Distribution: Widely distributed; bile, CSF. Protein-binding: 70%

Extensive hepatic first-pass metabolism; converted to albendazole sulfoxide.

Via bile; via urine (small amounts). 8.5 hr (elimination half-life).

MIMS Class:

ATC Classification
: P02CA03 -  albendazole;  Belongs to the class of benzimidazole derivative agents. Used as antinematodal.
Reference: mims

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